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The Top Peptide Serums Skin Experts Can’t Stop Recommending
You’ll want to add these to your skin care regimen ASAP.
The more you expand your skin care knowledge, the sooner you realize that retaining hydration, improving signs of aging, and boosting plumpness involves more than just your average hyaluronic acid or vitamin C formulas. Turns out, we should really be paying closer attention to peptides in skin care, which enhance skin elasticity and encourage collagen production for a firmer, more youthful glow.
“Peptides are short chains of amino acids that play a key role in communication between cells,” says Dr. Daniel Friedmann, a board-certified dermatologist at Westlake Dermatology & Cosmetic Surgery. “When applied on the skin, they can increase the production of proteins such as collagen, elastin, and fibronectin, leading to improvements in fine lines and wrinkles, elasticity, and firmness.”
Our top picks for the best peptide serums in 2024
Of course, like vitamin C and vitamin A, peptides come in a variety of forms (hundreds!). In skin care specifically, you’ll see a lot of carrier, signal, and neurotransmitter peptides. “Carrier peptides deliver trace minerals to boost collagen, while signal peptides signal different areas of the skin to promote elastin, collagen, and other proteins,” says Dr. Harold Lancer, board-certified dermatologist and founder of Lancer Skincare. “And neurotransmitter peptides are known for their Botox-type benefits.” While neurotoxins like Botox paralyze our muscles to smooth and prevent wrinkles, neurotransmitter peptides block the chemicals that trigger muscle contractions.
Intrigued? Below, you’ll find a list of top options for serums containing peptides; we selected them after interviewing three board-certified dermatologists, consulting with ELLE editors for their favorites, and reviewing numerous customer reviews. Below, discover the 14 best peptide serums for a plump, dewy complexion.
Pros
Cons
From the brain of an esthetician, Peach and Lily’s offerings understand that supple, smooth skin shouldn’t require aggressive formulas that can do more harm than good. Soothing, reparative, and nourishing, the Glass Skin serum enhances radiance and reduces fine lines and wrinkles through a blend of peptides, hyaluronic acid, and niacinamide.
Key ingredients: Peptides, peach extract, hyaluronic acid, niacinamide
Skin type: Normal, dry, combination, and oily
Size: 1.35 fl. oz
Ulta rating: 4.6/5 stars
An ELLE editor says: “As an acne-prone girl, glass skin is what I so desperately want to achieve, but sadly, the journey there has been fraught with a compromised barrier, more breakouts, and a hole in my wallet. I found relief in this serum, which combines my favorite ingredients—hyaluronic acid, niacinamide, and peptides—to give me bouncy, smooth, and soft skin. Tackling these dark spots is next on the list.”—Nerisha Penrose, ELLE.com beauty commerce editor
Pros
- Absorbs quickly
Cons
- May pill when layered with some products
This serum is about as straightforward as it gets—it promises to deliver an infusion of peptides, and that’s exactly what it does. A whopping 30 percent of the formula is a combination of multiple peptides that plump and smooth the skin with each use. Because it’s so gentle, you can even layer it with other actives like retinol.
Key ingredients: Peptides, panthenol
Skin type: Normal, dry, combination, and oily
Size: 1 fl. oz.
Dermstore rating: 4.8/5 stars
An ELLE editor says: “Every morning begins with this Liquid Peptide serum. No matter what my skin is going through, the serum revives it, adding plumpness and softness in just a few uses. I pair this with the Medik8 retinol, my powerhouse duo that keeps signs of aging at bay.”—NP
The Ordinary Multi-Peptide + Copper Peptides 1% Serum
Pros
- Fragrance-free
- Tightens skin
Cons
- Takes time to see results
King recommends this peptide serum that is anything but ordinary. The vegan formula combines several peptide complexes with a probiotic complex in a base of hyaluronic acid and amino acids. It’s designed to target fine lines, wrinkles, and other signs of aging.
Key ingredients: Copper peptides, Matrixyl, ARGIRELOX
Skin type: Normal, dry, combination, and oily
Size: 1 fl. oz.
Ulta rating: 4.2/5 stars
An Ulta reviewer says: “I have used this product as part of my regimen for over a year, and I can see a noticeable difference in deep wrinkles, and the slight ones are gone. I am over 60 years old and have previously taken great care of my skin. Peptides are great for skin and combined with copper peptides—over time, expect a mini miracle.”
Pros
- For face and neck
- Tightens and firms skin
Cons
- Not suitable for sensitive skin
Although this serum comes with a hefty price tag, it contains seven different peptides formulated to minimize the appearance of fine lines around the eyes, mouth, and forehead. The product should be applied before moisturizer, and you can expect to see noticeable results in as little as three months.
Key ingredients: Palmitoyl Hexapeptide-19, Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Dipeptide Diaminobutyroyl Benzylamide Diacetate
Skin type: Combination, mature, dry, oily
Size: 0.5 fl. oz.
Dermstore rating: 4.6/5 stars
An ELLE editor says: “Using this serum after a fresh cleanse feels like a splash of water on a rather hot day. I typically use this serum at night because I enjoy how plump and soft my skin feels upon waking up.”—Nerisha Penrose
Charlotte Tilbury Charlotte's Magic Serum Crystal Elixir
Pros
- Lightweight formula
- Suitable for daily use
Cons
- Unpleasant fragrance
Individuals of all skin types will benefit from this peptide serum, made with golden vitamin C and niacinamide to minimize the appearance of dark spots and brighten skin. Dr. Hadley King, a board-certified dermatologist specializing in medical and cosmetic dermatology, recommends this serum since it contains two anti-aging peptides, acetyl tetrapeptide 9 and 11, which may help to improve skin elasticity and firmness.
Key ingredients: Golden vitamin C, niacinamide, polyglutamic acid
Skin type: Normal, dry, combination, and oily
Size: 1 fl. oz.
Sephora rating: 4.2/5 stars
Our expert says: “I got this product in a holiday package and was instantly hooked. If you want hydrated, glowy skin, use this serum. It performs as well as my fancy serums for a fraction of the price. The minute I apply, my skin immediately looks luminous. This serum increases hydration and prevents skin water loss, making it great to apply before makeup. My favorite combo is using this with the Charlotte Tilbury Magic Water Cream when I want a long-lasting makeup look.”—Danielle James, beauty expert
Timeless Skin Care Matrixyl®️ Synthe'6®️ Serum
Pros
- Clean formula
- Enhances collagen production
Cons
- Too drying for some
Formulated with polypeptide Matrixyl®️ Synthe'6®️ and plumping hyaluronic acid, this peptide serum enhances collagen production and reduces the appearance of wrinkles and fine lines. It is best suited for dry and mature skin, but it can be used on all skin types.
Key ingredients: Matrixyl®️ Synthe’6
Skin type: All skin types, dry and mature
Size: 1 fl. oz.
Target rating: 4.7/5 stars
An Amazon reviewer says: “This has softened my 72-year-old skin. I use a few drops on my face, neck, upper chest, hands, and forearms—it does not take much!. It is lessening the deep wrinkles on my face and the crepey skin on my forearms. I saw a difference in my skin within four weeks.”
Mirabella Replenish and Restore Multi-Peptide Facial Serum
Pros
- May help with acne
- Gluten and paraben free
Cons
- Can leave a residue behind
For individuals struggling with excessive redness, this peptide serum can provide a more even complexion. The hyaluronic acid and vitamin C mix reduces discoloration while simultaneously soothing and softening skin. For best results, it’s recommended to use this formula twice a day, in the morning and at night.
Key ingredients: Cornus extract, gentiana scabra root extract, niacinimide
Skin type: Sensitive, oily, dry, combination
Size: 3 fl. oz.
Amazon rating: 4/5 stars
An Amazon reviewer says: “All the best ingredient in this lovely silky smooth serum that leaves my face totally hydrated and smooth. Visible results after just a few days of use. My skin feels twenty years younger!”
Peter Thomas Roth Peptide Skinjection Amplified Wrinkle-Fix Refillable Serum
Pros
- Minimizes the appearance of expression lines
- Fragrance-free
Cons
- Need to exfoliate before use
Formulated with a 19 percent peptide complex, this serum works to reduce the appearance of fine lines and wrinkles for a smooth complexion. It’s also designed to accompany injectable treatments, minus a trip to the dermatologist.
Key ingredients: Amplified Matrixyl, argireline
Skin type: Oily, combination, normal
Size: 1.01 fl. oz.
Sephora rating: 4.5/5 stars
An Amazon reviewer says: “I’ve almost used a full bottle, and I can definitely see my fine lines and wrinkles looking plumper and smoother. I love that it’s lightweight—[it does] not feel heavy under any moisturizer or makeup. Will continue using.”
Pros
- Ideal for dull, uneven skin
- Can be used on face and neck
Cons
- Small bottle for the price
This serum, which contains L-ascorbic acid (the most effective form of vitamin C) and a copper tripeptide growth factor, is beneficial for individuals with discoloration. The formula can be spread over the face and neck to reduce the appearance of stretch marks, scar tissue, and acne.
Key ingredients: L-ascorbic acid (vitamin C)
Skin type: All
Size: 15 mL
Dermstore rating: 4.6/5 stars
A Dermstore reviewer says: “This is my holy grail serum in my morning routine. I have healed all my acne and use this as my daily vitamin C to aid in healing atrophic acne scars and hyperpigmentation.”
Clearstem Bounceback No Botox Serum
Pros
- Improves overall skin texture
- Can help UV skin damage
Cons
- May experience pilling
Looking to enhance your collagen levels? This serum combines growth factors, peptides, and stem cells to help stimulate collagen production and repair damaged skin. You’ll also notice a soothing effect with its botanical ingredients, including reishi and B5, providing a spa-like experience with each use.
Key ingredients: Argan oil, stem cells
Skin type: Dry, oily, mixed
Size: 1 fl. oz.
Clearstem rating: 4.9/5 stars
A Clearstem reviewer says: “I think this serum is a great addition to my skincare routine. I love the smell and simplicity of it. I struggle with both acne and wrinkles, so having an option for helping both has been great! I am on my second bottle.”
Pros
- Cruelty-free
Cons
- May not be suitable for very dry skin
Devoid of over 1,680 substances restricted by the FDA and European Union Cosmetics Regulation Guidelines, this clean serum is suitable for daily use. It uses a polypeptide complex to minimize the appearance of fine lines and wrinkles while enhancing brightness. Plus, it features multiple weights of hyaluronic acid for a refreshing burst of hydration.
Key ingredients: Poly-peptide complex, marine bamboo, hyaluronic acid
Skin type: Normal, dry
Size: 1.01 fl. oz.
Ulta rating: 4.6/5 stars
An Ulta reviewer says: “This stuff is awesome. A little bit goes a long way. I call it botox in a bottle because it tightens your skin up and minimizes wrinkles.”
Pros
- Tightens and firms skin
- Great for under makeup
Cons
- May not be suitable for sensitive skin
Although skin loses its elasticity as time passes, there are ways to keep it tight and firm. This serum contains Retinol 8, which is designed to be gentler on the skin, and peptides to brighten, hydrate, and soften for a smoother complexion. The brand recommends applying the serum at night for optimal results.
Key ingredients: Retinol 8, tumeric, peptides
Skin type: Combo, mature, dry, oily
Size: 1 fl. oz.
Amazon rating: 4.4/5 stars
An Amazon reviewer says: “Super expensive but it is a GREAT product! It cleared my skin completely up in about three weeks and I use it before I put my makeup on now.”
Pros
- Lightweight formula
- Clean ingredients
Cons
- Instructions can be difficult to follow
Not looking to spend a lot of money on a peptide serum? Luckily, The INKEY List offers a high-grade formula for $16 per bottle. Packed with two types of peptide complexes, the lightweight serum aims to stimulate collagen production and reduce the appearance of fine lines for a smoother complexion. For best results, apply a pea-sized amount to the face and neck in the morning and at night.
Key ingredients: Matrixyl 3000, Syn-Tacks
Skin type: Normal, dry, combination, oily
Size: 1 fl. oz.
Sephora rating: 4.3/5 stars
A Sephora reviewer says: “For the price, I’m blown away by how much hydration and plumping this gives my skin.”
Pros
- Helps repair damaged skin
- Designed for face and neck
Cons
- May pill on the skin
This cruelty-free serum contains polypeptides to help increase collagen and elastin production for smoother and tighter skin. It’s particularly beneficial for individuals with dry skin as it is hydrating and moisturizing with its use of hyaluronic acid.
Key ingredients: Polypeptides, pomegranate seed oil, hyaluronic acid
Skin type: Normal, dry, combination, oily
Size: 1.01 fl. oz.
Sephora rating: 4.7/5 stars
A Sephora reviewer says: “I’ve noticed a visible change in the firmness of my skin and my fine lines. Others made comments on how my skin is looking firmer, too, so it’s not just me! It doesn’t break me out, it actually keeps my skin really smooth and sits well under makeup.”
Kiehl’s Since 1851 Micro-Dose Anti-Aging Retinol Serum
Pros
- Should be gentle
- Minimizes pore size
Cons
- May take time to see results
Instead of a traditional pore minimizer, opt for this anti-aging serum that combines retinol, peptides, and ceramides to tighten and tone skin. The lightweight, creamy formula keeps skin looking youthful and even-toned with consistent use.
Key ingredients: Pure retinol, ceramides, peptides
Skin type: Normal, oily, dry, combination
Size: 1 fl. oz.
Sephora rating: 4.5/5 stars
A Sephora reviewer says: “I used this now for about a month…at first I was using it every other day and progressed to every day now. My skin has never looked clearer. My fine lines have faded so much, my acne scars are fading, and I haven’t gotten a single breakout since.”
Meet the Experts
Dr. Hadley King is a board-certified dermatologist, specializing in medical and cosmetic dermatology.
Dr. Harold Lancer is a board-certified dermatologist and founder of Lancer Skincare.
Dr. Stefani Kappel is a board-certified dermatologist and founder of MDAiRE.
Dr. Daniel Friedmann is a board-certified dermatologist at Westlake Dermatology & Cosmetic Surgery.
Rheanita Reese is a licensed esthetician and shop manager of Heyday Preston Hollow.
What are peptides?
Peptides naturally occur in the body and, like proteins, are composed of amino acids and influence the cells of the body. “For example, if your skin is losing collagen, peptides can be used to signal the skin to produce more,” says King. “In other words, they act as chemical messengers and are often referred to as signal peptides because they tell cells what to do.”
Friedmann tells ELLE.com that peptide serums pair very well with retinol, sunscreens, and antioxidant products like vitamins C and E. That said, alpha-hydroxy acids can degrade peptides (through a process called acetylation), which decreases their efficacy.
What are the skin benefits of peptides?
Peptides have numerous benefits, which vary based on the formula and ingredients. “Some may stimulate collagen production in the skin, others may stimulate skin cells to turnover more quickly, and others may inhibit the release of neurotransmitters to keep facial muscles from forming wrinkles,” says King.
Dr. Stefani Kappel, board-certified dermatologist and founder of MDAiRE, adds that peptides can enhance skin hydration, support wound healing, and target specific skin concerns. “They may also have antioxidant or anti-inflammatory properties,” she adds.
Who should be using peptide serums?
Everyone can benefit from peptide serums, especially as a preventative measure for common skin concerns that occur with aging. “They are most useful for anyone in their mid-20s and up,” says Lancer, adding that “peptides will help with the bounce and elasticity in the skin, collagen, and tone.”
Still, Kappel says individuals with specific skin conditions or allergies should consider consulting with a dermatologist before incorporating peptide serums into their routine.
How long does it take to see results from peptide serums?
According to Friedmann, the benefits of peptide serums can be seen as early as a few weeks, but it can take up to three to four months to see the full results of an at-home treatment.
Rheanita Reese, a licensed esthetician, adds that the skin conditions being targeted will impact how long it will take to start noticing results.
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